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Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

Join us for this exciting opportunity in the Biomeasures group in Pfizer Andover applying cell-based assays, proteomics, and quantitative protein LCMS to transformative mRNA/LNP, small molecule, and biotherapeutics projects. The role will primarily develop protein mass spectrometry and targeted proteomics assays to measure concentrations and turnover of targets of biotherapeutics in a variety of biological matrices as well as transgene protein expression from mRNA-LNP therapies. The successful applicant will display particular interest and expertise in sample preparation and enrichment techniques including protein and peptide immunoaffinity in conjunction with LCMS using high resolution and triple quadrupole MS and/or ligand binding assays (LBA). The successful applicant will join a state-of-the-art laboratory with deep expertise in protein quantification and is expected to build strong collaborative partnerships, both within and outside the group. This position requires bioanalytical sample preparation expertise, some background in protein biochemistry and proteomics, and documented experience utilizing triple quadrupole and high-resolution quantitative mass spectrometry. This position will work in project teams and interact with modelling & simulation experts, project leads, biologists, and protein engineers.

How You Will Achieve It

• Responsible for the development, qualification and implementation of transgene protein, target biomeasure and pharmacodynamic biomarker assays using mass spectrometry in support of discovery and translational projects.

• Works with group lead or other biomeasure team members and project team members to accomplish goals.

• Participates in technology development and implementation by exploring new workflows to expand the group's biomarker bioanalytical capabilities.

• Participate in all phases of laboratory operations including technology evaluations, the development of sample preparation and separation methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.

• Ensure all tasks and responsibilities are carried out according to scientific and ethical standards e.g. responsible for electronic notebook record keeping; QC and peer review of data and reports.

Qualifications

Must Have

• MS with a Science Degree with have 4 to 7 years of relevant work experience, ideally mostly in industry OR Bs Science field, with 6 years of experience

• Expertise in development, characterization, and implementation of bioanalytical assays by LCMS and/or LBA. Including deep knowledge of sample preparation procedures for proteins, small molecules, lipids, etc. from a variety of matrices

• Experience in operation of triple quadrupole and ion trap/orbitrap mass spectrometers and associated control and data analysis software systems.

• Knowledge of protein biochemistry and proteomics techniques.

Nice To Have

• Experience in instrument programming in the pursuit of lab automation will be considered.

• Experience in the preparation of tissue samples for analysis will be considered.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• Fully on-site, lab-based position requiring performance of all typical laboratory related activities

• Based in Andover, Massachusetts with occasional travel to Cambridge (Kendal Square) is required, depending on project needs

Work Location Assignment:On Premise

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development