We Hire America Jobs

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

Summary

We are seeking a motivated and enthusiastic individual to perform binding kinetics using surface plasmon resonance (SPR) and biolayer interferometry (BLI) to support the Oncology Research Unit at Pfizer. The primary objective of this position is to aid in the characterization of small molecules for multiple programs, with additional responsibilities in protein-protein interactions when priorities shift. The candidate will design and execute experiments, analyze data, and interpret results to support various research projects. The ideal candidate should have a strong background in biochemistry, experience with binding kinetics assays, and excellent problem-solving skills. Collaboration with cross-functional teams is essential, offering an opportunity to contribute to innovative research in a dynamic and collaborative environment.

Principal Responsibilities

• Design and perform small molecule and protein-protein binding kinetic experiments using BLI and SPR.

• Analytical characterization of proteins via analytical SEC, mass spectrometry, SDS-PAGE, UV-Vis, intrinsic fluorescence, or related techniques.

• Biotinylation of recombinant proteins.

• Process proteins including buffer exchange, protein concentration adjustment, aliquoting, and storage.

• Manage and track binding requests and samples.

• Data analysis, report generation, and presentation of results.

• Document all work in an electronic laboratory notebook.

• Balance workload and changing priorities to efficiently contribute to kinetic research collaborations.

Required Qualifications

• Bachelor's degree in Biological Sciences or related discipline with 3+ years lab experience in an academic and/or industry environment.

• Experience with performing protein binding kinetics (Biacore/Octet).

• Strong understanding of experimental design and familiarity/experience with basic biochemical principles and techniques.

• Strong attention to detail while following protocols and with data representation.

• Commitment to high quality analysis and documentation with the ability to organize, analyze and interpret, and effectively communicate individual results.

• Ability to perform routine tasks independently, more advanced tasks under direction and complete work as part of a team.

Preferred Qualifications

• 1-3 years of experience with performing and designing binding kinetics assays on Octet, Biacore, Carterra, or other related protein kinetics instruments, especially with a focus on small molecule binding and screening.

• Strong understanding of sensorgram analysis theories.

• Tracking inventory and/or requests through computer systems, Smartsheet, or Excel.

• Basic knowledge of antibody biochemistry, understanding of immunological functions and systems.

• Experience with labeling proteins with a small molecule like biotin.

Additional Information:

• Relocation support available

• Eligible for Employee

• Work Location Assignment:On Premise

• Last Day to Apply: October 11, 2024

The annual base salary for this position ranges from $64,600.00 to $107,600.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development