Pfizer Scientist, Biotherapeutic Protein Purification and Conjugation in Cambridge, Massachusetts
WHY PATIENTS NEED YOU
Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.
Pfizer's BioMedicine Design (BMD) is seeking a highly motivated and experienced protein biochemist to join the high-energy and dynamic Biotherapeutic Expression and Purification group (BEP), which is responsible for generating non-GMP protein drug leads to support various Pfizer research units and their in-vitro and in-vivo needs in pre-clinical development. Qualified candidate will play an essential role in cross-functional team and will be responsible for processing of mammalian- and bacterial-expressed recombinant protein modalities including, but not limited to multispecific antibodies and conjugation of payloads to the antibodies, using state-of-the-art technologies and equipment. The candidate will contribute to the group-wide deliverables in highly collaborative environment and be required to work on several projects simultaneously presenting results and updates at group and project team meetings.
Support the development of scalable protein purification processes, and ensure timely delivery of highly purified biotherapeutic candidates to discovery project teams
Assess quality of biotherapeutics rigorously and review all analytical documentation prior to protein release
Routinely provide updates at project meetings
Proactively evaluate new technologies and implement new features and functionality into discovery pipeline
Drive technology innovation. Maintain knowledge of scientific trends industry processes through readings, conferences and seminars; review literature to advance manufacturing procedures and methods
Will be involved in the design and execution of projects with the ability to operate independently
Work closely with multidisciplinary teams including therapeutic discovery teams, research units, bioanalytical teams, transient expression and stable cell line development groups, engineering leads, and R&D project leaders
MS with 3+ years or BS with 5+ years of relevant experience in Biochemistry, Biology, Biological Engineering or a related discipline along with a solid understanding of protein purification
Hands-on experience with protein purification (using affinity and traditional chromatographic techniques) on AKTA chromatography systems, including operating Unicorn and OpenLab CDS software packages.
Hands-on experience with protein conjugation
Hands-on experience with analytical biochemistry and experience in protein analytical characterization, including mass spectrometric analysis of protein
Able to work effectively in cross functional teams to solve process development problems or implement improved procedures
Strong written and verbal communication skills
Organized, detail oriented, multi-task, and remain flexible with changing needs
Must be self-motivated and able to work under strict timeline
Prior industry experience in antibody purification
Experience with DOE concepts and tools
Python and/or VB experience
Involves typical bioprocessing lab activities
Ability to routinely lift 50 lbs
Standing for prolonged periods of time, walking, bending, and using tools
Ability to perform mathematical calculations and ability to perform complex data analysis
Work Location Assignment:On Premise
The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
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EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.
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