Merck Senior Scientist, Cardiometabolic Geneticist in Cambridge, Massachusetts
Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.
Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and consumer health products, as well as animal health products. Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for all of us. Our company is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. To this end, our company is intentionally at the forefront of applying genetics, genomics, and biological data science to advance breakthrough science and drug development across therapeutic areas.
Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career.
The Genetics and Pharmacogenomics (GpGx) department at our research laboratory is currently seeking a senior scientist with strong expertise in human genetics for Cardiometabolic disease at the Boston site. Our mission in the Early Discovery Genetics (EDG) group within GpGx is to identify and functionally validate novel targets anchored in human genetics that will enter our company's drug discovery pipeline for therapeutic intervention. The successful candidate will be team-oriented, with the ability to effectively communicate and thrive in an inclusionary, integrated, and multidisciplinary work environment. The Senior Scientist will report into Cardiometabolic Genetics Lead within EDG and be responsible for the following:
Integrate data from large human genetic datasets, including Genome-Wide Association Study (GWAS), RVAS, Expression quantitative trait loci/quantitative trait loci (eQTL/pQTL) studies, and Mendelian genetics, to identify potential therapeutic targets for Cardiometabolic disease areas.
Collaborate closely with our Cardiometabolic Disease organization, statistical genetics colleagues and external partners to conceptualize, execute and apply genetics and genomics research for target identification.
Formulate functional validation studies of genetics targets in collaboration with experimental scientists in GpGx-EDG, Cardiometabolic colleagues, pharmacologists, chemists and external partners for validation of the genetics targets for early discovery pipeline.
Provide genetics expertise to biologists and leadership in cardiometabolic disease with ability to communicate results, conclusions and application of genetics to impact the pipeline
Participate in large academic/industry partnerships and leverage data from large biobanks (including FINNGEN, UK Biobank), as well as explore and identify new external collaborations with academia and industry partners to leverage tools to exploit human genetics/genomics in to discover new drug targets.
Spearhead both internal and peer-reviewed publications and presentations.
- PhD or MD/PhD with 3+ years of postdoctoral experience in genetics, cardiometabolic diseases or related fields.
Proven track record and understanding of human genetics in disease areas such as Liver, Heart Failure, Fibrosis, Immuno-metabolic and Eye diseases to identify potential therapeutic targets.
Extensive experience in analyzing large-scale genetic datasets as well as integrating genomics, epigenomics and proteomics data to generate causal gene hypotheses with strong bioinformatics, statistics and data management background.
Strong understanding of clinical/pathobiology functional readouts in diseases for identifying translatable targets based on human genetics.
Experience in translating genetics findings into functional assays to provide insight into biological mechanism.
Strong communication, collaboration, and leadership skills including ability to distill and communicate complex genetic/genomic concepts to scientists from diverse disciplines.
- Experience with integration diverse high-throughput data types, as well as with big data architecture and visualization.
The geographic location of this position is in Boston MA.
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth .
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Requisition ID: R85186
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