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Job Description

Our Company is on a quest for cures and is committed to be the world’s premier, most research-intensive biopharmaceutical company. Today, we are doubling down on this goal. Our Company's Research Laboratories is a true scientific research facility of tomorrow and will take our Company's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology we collaborate to discover the next medical breakthrough.

Our company is seeking a highly motivated candidate for the position of Senior Principal Research Scientist (Senior Director) of Immunology Discovery research, reporting to the Executive Director of Autoinflammation, Autoimmunity and Atopy (AAA) in Immunology Discovery. This position is a senior role, responsible for leading an Immunology research group focused on Autoinflammation therapeutics and Companion Diagnostics (CDx).

We recognize team diversity as our strength and are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission.

In this position key responsibilities are

• Lead a team of scientists (Ph.D. and Non-Ph.D.) that advances multiple research projects for Autoinflammation from target validation through Candidate Selection (GLP Tox Nomination) stages through effective leadership of matrixed, multi-disciplinary teams with membership from Immunology Discovery, Quantitative Biosciences (pharmacology), Translational Medicine, Preclinical safety, DMPK-BA, CMC, Clinical development and Commercial.

• Lead, in partnership with Digital AI and Genomics Sciences (DAGS), a research team that envisions, develops and implements integrated approaches for patient profiling methodologies and assay development to deliver companion diagnostics (CDx) and biomarkers for disease monitoring and patient stratification.

• The candidate must have strong people management skills and excel in creating high performing teams to conduct scientific research and to translate breakthroughs in fundamental science to develop world class human health products.

Primary Responsibilities:

• Shape and lead program strategy in the context of autoinflammatory diseases.

• Provide expertise in immunology; anticipate future trends within this scientific discipline.

• Partner with Research, Translational, and Clinical colleagues to manage early and late-stage discovery programs including FIH and POC clinical studies.

• Define clear objectives, vision for each project and set short- and long-term project strategies.

• Partner with DAGS to innovate translational/biomarker/CDx approaches for novel therapeutic concepts or modalities for immune-mediated diseases.

• Develop talent and strategically maximize diversity to strengthen their team.

• Foster a high-performance culture of collaboration, engagement, accountability, and inclusion.

• Effectively partner with leaders of the Autoimmunity and Atopy disease area within the AAA team and other therapeutic area (TA) functions to achieve the organizational objectives of the Immunology TA.

• Collaborate with organizational partners to sustain and foster a culture of integration, innovation and continuous improvement in drug development.

• Establish cross functional collaboration and support in the preparation of INDs and other submissions to health agencies for human clinical studies.

Education Minimum Requirements:

• Advanced Degree (Ph.D., MS, BS or equivalent) in immunology, pharmaceutical sciences or a related field.

Required Experience and Skills:

• PhD in Immunology/Cell biology or related field, with 10+ years of immunology research experience, MS with 15+ years of immunology research experience, or BS with 20+ years of immunology research experience. Must have at least 7 years of direct industry experience.

• Knowledge and experience of immune-mediated diseases including a strong understanding of relevant clinical trial results and competitive landscape in immunology and autoinflammation.

• Experience developing clinically relevant biomarkers for target engagement and pharmacodynamic measures.

• A minimum of 5 years of direct management experience overseeing multiple teams and proven leadership with the ability to align, motivate and empower team members and a demonstrated passion for team building and talent development.

• Experience in compound (small molecules and biologics) discovery and design for a variety of relevant disease targets.

• Strong awareness of safety and environmental requirements.

• A good understanding of integration and partnering necessary for pharmaceutical development with Translational Medicine, Clinical, CMC, Regulatory, Operations, and other functional areas.

• Critical thinking ability and innovative mindset.

• Effective communication, collaboration, and negotiation skills with the ability to work with senior level managers in meeting venues that include multiple cross-functional representatives.

Preferred Experience and Skills:

• Prior experience leading the development of CDx assays to enable precision patient profiling and inform strategies for therapeutic intervention.

• Experience developing and validating innovative methodologies to monitor disease progression and therapeutic efficacy in a variety of clinical settings and disease indications.

• Experience in collaborating with Search & Evaluation teams to evaluate external business development opportunities that complement existing internal programs.

• Experience with regulatory submissions and interactions with health authorities is desirable.

#EligibleforERP

Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)

Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights (https://www.eeoc.gov/sites/default/files/2022-10/22-088_EEOC_KnowYourRights_10_20.pdf)

EEOC GINA Supplement​

Pay Transparency Nondiscrimination (https://www.dol.gov/sites/dolgov/files/OFCCP/pdf/pay-transp_%20English_formattedESQA508c.pdf)

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/)

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

04/8/2025

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R340895