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Job Information

Pfizer Sr. Director, Rare Disease RWE Scientist in Collegeville, Pennsylvania


The Real-World Evidence (RWE) Center of Excellence (CoE) is an innovative, rapidly expanding group that provides end-to-end evidence optimization, education, communication, and maximization of data partnerships' value within therapeutic areas (TAs) across Development, Regulatory and Commercial needs to support breakthroughs to change patients' lives.

Pfizer Rare Disease (RD) strives to advance science and translate this knowledge into high-impact medicines for rare disease patients. The TA has made landmark contributions to the RWE field and has engaged with strategic partners to further advance RWE from clinical development to marketplace.

Within the global RWE CoE, the Senior Director will partner closely with the RD RWE Lead and drive internal and external senior engagement, strategy and execution. He/She will act as a deputy for the Lead in advising on and championing the use of RWE across the product lifecycle with RD leadership and key senior internal stakeholders, providing additional support to high complex RWE projects. He/She will also create and maintain relationships with external stakeholders to advance Pfizer's RD goals. This includes working with existing and potential data partners to maximize value generation and plan for innovation; with regulators and government agencies to be at the forefront of shaping RWE perspectives, policies, and use; and with other key partners. He/She will be expected to represent Pfizer RD on high visibility initiatives and at industry forums and conferences.

The Senior Director will advance and deliver against RD's RWE strategy, will ensure end-to-end RWE needs of franchise/asset teams are being met, and will deliver RWE educational and data/tool training sessions and communications to advance the use of RWE across the organization. He/She also will oversee their team's progress against strategic goals, provide updates on milestones, help his/her team to troubleshoot, escalate issues as needed, create ROI or other reports/presentations for diverse audiences.


  • Champion the full integration of RWE across the asset lifecycle for the RD TA, identifying opportunities for bold moves in RWE application

  • Direct a team of highly matrixed cross-functional operational leaders to prioritize strategic RWE capabilities, create roadmaps and assess potential new partners' ability to drive innovation and fill gaps

  • Direct, supervise and motivate a team of RWE Scientists to execute on a detailed end-to-end RD RWE strategic plans, tactics, methods, approaches and designs for a set of RD assets and indications

  • Partner with RWE Lead to proactively support the leadership and key stakeholders

  • Collaborate with GPD and Biopharma functions to develop RWE plans and deliverables for assigned assets and indications.

  • Lead the team to design and coordinate key/priority aspects of epidemiologic RD research programs, including study design, protocol preparation, directing design and preparation of data collection forms and data tabulations, preparing data summaries/reports, publications (e.g. scientific manuscripts, abstracts, posters, internal and external presentations), systematic reviews, and technical reports.

  • Oversee and coordinate scientific activities related to assigned indications to ensure integration of this information into overall development programs.

  • Lead teams and external partners to maximize value generation from existing partnerships and propose new external partnerships to fill gaps in RWE capabilities to drive Pfizer RD's goals forward

  • Track innovative and emerging RWE analytical approaches, guidelines, and tools; global regulator, HTA and payer acceptance of RWE; create plans for integrating these learnings; and direct high visibility external RWE initiatives


Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

  • 8+ (PhD/PharmD/ScD/MD or other advanced degree) or 13+ (with a master's degree) years of experience in Epidemiology, Biostatistics or closely related field

  • Proven track record of leading a team in non-interventional research, other clinical/translational research, or similar trials, studies or initiatives to deliver timely, credible results through teamwork and collaboration

  • Proven ability to influence and succeed through others and to form excellent relationships with key cross-functional stakeholders.

  • Demonstrated strong technical writing skills with a track-record of publishing in peer-reviewed journals and medical/scientific conferences.

  • Able to set priorities and manage cross-functional teams and complex projects to deliver milestones according to budget

  • Knowledge of and experience with critical business areas such as regulated drug research and development (e.g., RCTs), innovative trial designs incorporating RWE, post-marketing regulatory application of RWE, HEOR studies for publications or dossiers, value-based contracts/care, or RWI to support business development decision-making purposes

  • Experience in supporting multi-institutional initiatives involving data, standards, and/or technology leveraging strong experience in communicating results in simple verbal and written/graphical form with all levels of personnel


  • PhD/PharmD/MD/other advanced degree with 10+ years of experience working to generate RWE and apply innovative methods & solutions in Medical Affairs, Research & Development, or similar environment

  • Track-record in publications about the development, evaluation, and/or other aspects in high-impact peer-reviewed journals.

  • Able to independently formulate and execute clinical development plans or lifecycle strategy.

  • Demonstrated ability in the design, initiation, and reporting of clinical studies as part of an integrated clinical plan.

  • Ability to discuss scientific aspects of drug development, also comfortable in discussing commercial and regulatory issues.

  • Experience with Sickle Cell Disease, Hemophilia, Duchenne's Muscular Dystrophy, rare cardiac conditions, or other Rare Disease areas highly desired


Standard working hours expected, but may be required to intermittently work longer hours during periods of high demand. Limited travel to attend key internal business meetings or conferences required.

Other Job Details:

Last Date to Apply for Job: March 31st, 2023

Additional Location Information: US - remote

Eligible for Relocation Package: No


The annual base salary for this position ranges from $185,800.00 to $309,600.00. In addition, this position offers an annual bonus with a target of 22.5% of the base salary and eligibility to participate in our share based long term incentive program. Benefits offered include a retirement savings plan, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage in accordance with the terms and conditions of the applicable plans. Salary range does not apply to the Tampa, FL location.

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

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