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Job Information

Pfizer Cellular and Mechanistic Investigative Toxicology Lead in Groton, Connecticut


This is a leadership role in the DSRD Discovery, Investigative and Translational Sciences group, accountable for strategic, operational and scientific aspects of the cellular and mechanistic investigative toxicology laboratory. The lead reports to the Global Discovery, Investigative and Translational Sciences head and with this partnership will develop the operational and strategic vision and deploy resources accordingly. There will be an expectation to 'engage the external environment' (e.g., influence screening, species selection, regulatory guidance and evolving scientific thinking). Develop the future talent by engaging in technical and scientific competency of line staff resulting in increased engagement and external recognition. Ensure appropriate quality of study conduct and reporting. This includes maintenance of appropriate compliance standards (e.g. EHS) and where necessary GLP.


  • Accountable for setting the strategic, operational and technical direction of the cellular and mechanistic toxicology laboratories and appropriately deploy resources

  • In partnership with sub discipline heads will be responsible for engaging in strategic planning and centralization of laboratory capabilities, maintaining quality and consistency of the laboratory data, interpretation and reporting, coordinates with project teams to provide high quality technology expertise and support

  • Works with key scientific staff to align resources to project priorities, timelines, and Tracks investigative tox projects and makes available to GDITS leadership for endorsement

  • Oversee the use and maintenance of laboratory space, and oversees capital equipment requests with the support of the other laboratory leads to ensure reducing redundancies and building new capabilities.

  • Continuously investigates new techniques and improvement of current practices.

  • Participates in cross-functional activities (e.g., Limited Duration Teams, Practice networks, etc.)

  • Evaluates and interprets experimental data, participates in external engagement activities, particularly those related to investigative sciences, professional societies and industry working groups

  • Provides Global Performance Management functions including interactive coaching and feedback sessions, development planning, midyear reviews, annual reviews, promotion reviews, and reward and recognition programs.


  • MS or equivalent in biology/biochemistry, toxicology, or related field with >15 years related experience; DESIRABLE: PhD with >8 years relevant experience.


  • Prior experience within investigative toxicology laboratory

  • Prior supervisory and mentoring experience

  • Experience in the development, characterization of safety issues, safety de-risking for novel modalities, conduct hypothesis-driven mechanistic research and active participant of issue management teams, implementation of Investigative screening, cellular based and mechanistic-based assays.

  • Demonstrated ability to work collaboratively and influence in a matrix organization

  • Extensive experience with software packages to enable data acquisition, data processing, and study reporting

  • Demonstration of excellent verbal and written communication skills, well organized, self-motivated, detail oriented, and has the ability to work and effectively communicate within a team environment

  • Knowledge of Good Laboratory Practices (GLP), data collection systems, and data processing applications

  • Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

Other Job Details:

Last day to apply: February 7, 2023

Relocation support available

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development