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Job Information

Pfizer Senior Associate Scientist in Groton, Connecticut

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

The Hit Discovery and Optimization group at our Groton campus leverages state-of-the-art bioanalytical technologies, automation and novel approaches for identification and biopharmaceutical characterization of lead chemical matter. We work in partnership with various disciplines to accelerate project progression and support the Pfizer portfolio as a whole.

What You Will Achieve

The qualified candidate will join a dynamic lab at the forefront of early drug discovery, employing an array of bioanalytical methodologies to detect new chemical entities in in vitro biopharmaceutical screening samples. The individual will also work collaboratively with partner lines to execute fit-for-purpose, high-throughput bioanalyses across established support platforms, and on development of new technologies/capabilities that accelerate discovery operations.

How You Will Achieve It

-Support high-throughput in vitro biopharmaceutical screening operations using liquid-chromatography and mass spectrometry (LC-MS)

-Collaborate with partner lines to develop and execute novel, fit-for-purpose high-throughput bioanalytical methods in support of hit validation and in vitro pharmacology

-Contribute to development of new capabilities and evaluation of emerging technologies

-Operate, maintain and troubleshoot specialized LC-MS instrumentation and platforms

-Document experimental results, perform critical review of data, and present findings internally and externally

-The colleague must be able to interact with peers and leaders in a multidisciplinary team, organize, prioritize and multitask effectively, and thrive in a fast-paced, innovative environment



  • BS in Analytical Chemistry, Chemistry, or Biochemistry with 2-4 years relevant laboratory experience, OR, MS in Analytical Chemistry, Chemistry, or Biochemistry with 1 -3 years relevant laboratory experience.

  • Hands-on experience with mass spectrometry including method development and regular use in research work (academia or industry)

  • Experience with in vitro laboratory techniques

  • Experience operating laboratory equipment and automation

  • A commitment to timely delivery of quality work and overcoming obstacles in a fast-paced environment

  • Demonstration of excellent computer, verbal and written communication skills


  • BS, MS in Chemistry or Analytical Chemistry with 3 years Pharma laboratory experience

  • Hands-on experience with liquid chromatography-mass spectrometry (LC-MS), including instrumentation and software.

  • Experience with small molecule LC-MS method development

  • Experience with plate-based in vitro techniques, in pharmacology or ADME studies.

  • Familiarity with liquid-handling automation

  • Familiarity with troubleshooting of analytical instrumentation and/or processes based on experimental data

  • An ability to collaborate with team members in immediate group and across disciplines

  • Strong command of Microsoft Office software suite


  • The position will require the scientist to work in the laboratory, including standing, walking, sitting, bending, and lifting.

  • Ability to perform practical laboratory bench work and work on a computer (while standing or sitting).

  • Ability to perform mathematical calculations and interpret data.

  • Skilled in written and spoken English.


Some travel (a few times per year) may be required to other Pfizer sites or to attend and present at scientific conferences.

Relocation support available

Work Location Assignment: On Premise

Relocation assistance may be available based on business needs and/or eligibility.

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development