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Role Summary

Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Scientist (non-PhD) to join the Post-Candidate Research (PCR) group, focused on translating basic discoveries in the field of immune oncology (IO) into novel therapeutics.

As part of our team, the Scientist will advance our clinical and pre-clinical drug programs in the field of immune oncology, focused on large molecule (biologic) therapeutics. The candidate will provide scientific and technical support and work closely with their manager and team members to generate decision-enabling data for novel drug combination strategies and mechanisms of action. A successful candidate will demonstrate experience with primary immune cell assays and a strong background in assay development. They will use a variety of techniques including flow cytometry, soluble cytokine analysis, and tissue culture assays.

Role Responsibilities

• Execute in vitro experiments including but not limited to compound dose curves, immune cell/cancer cell co-culture assays, and primary immune cell stimulation assays.

• Perform multi-color flow cytometry staining of cells or tissues, operate flow cytometers, and analyze flow cytometry data.

• Perform ELISA and MSD assays for cytokines and soluble biomarkers, graph results.

• Sterile tissue culture of primary cells and maintenance of cell lines.

• Highly detailed and diligent record keeping for all experiments, reagent stocks, and frozen reagent/cellular stocks.

• Record experimental protocols/results in detail and may contribute to technical reports in support of regulatory filings

• Communicate experimental findings accurately and concisely in both oral and written formats during weekly lab meetings.

• Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, and take a proactive role in personal growth and scientific development

Qualifications

Must-Have

• Bachelor of Science degree in Immunology, Cell Biology, molecular biology or related discipline.

• 6+ years relevant post-graduate industry experience or MS degree with 4+ years.

• Experience in standard aseptic cell culture techniques.

• Experience in immune cell isolation from a variety of tissues (blood, PBMCs, tissue) and characterization using multi-color flow cytometry.

• Experience immune cell assays including activation, differentiation, proliferation, cytotoxic and/or suppression assays.

• Attention to detail, in keeping up-to-date and thorough lab records for all lab reagents/assays/experiments.

Nice-to-Have

• Experience with T cell or myeloid cell differentiation and functional assays.

• Experience in writing technical study reports in support of regulatory filings.

• Drug Discovery and Oncology experience.

• Excellent organization skills and good verbal and written communication with ability to organize and prioritize work to meet timelines and deliverables.

• Strong motivation with a dedicated work ethic with ability to multi-task and work independently and efficiently in a fast-paced, highly collaborative team environment.

Work Location Assignment: On Premise

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development