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Job Description

Our company is committed to bringing life changing therapies to patients in need. With a patient-focused approach harnessing cutting-edge precision medicine, it is our mission to transform the landscape of immune diseases such as inflammatory bowel disease. We are leaders in the field of immunology and continue to lead with new indications and modalities.

The department of Immunology Discovery and Translational Sciences leads and supports our company's pipeline programs encompassing early target discovery and validation, drug discovery, translational medicine, and precision medicine in collaboration with bioinformatics team members.

Our company is recruiting a highly motivated, detail-oriented Associate Principal Scientist with a passion for improving patient lives to support internal discovery efforts. This individual will work in a matrixed environment with a focus on immune targets and leveraging genetics to stratify patients for drug treatment. We seek a motivated, versatile, detail-oriented Associate Principal Scientist to join the Immunology Discovery and Translational Team located in our San Diego site. The focus will be on preclinical and IND-enabling in vitro studies. The ideal candidate thrives in a fast-paced, matrixed team.

Job responsibilities:

• Lab-based role focusing on preclinical and IND-enabling studies for novel therapeutics for immunological diseases

• Design and execute in vitro functional assays to support target validation, drug screening, mechanism of action studies, and biomarker identification

• Keep detailed and concurrent records of experiments performed in an ELN, analyze and interpret data, and design subsequent experiments to address new questions that are raised.

• Present data to peers and management to facilitate collaboration and data-driven decision making

• Work collaboratively with other scientists in the group in a highly matrixed lab environment

Education:

• Ph.D. or MD in Immunology or related field of discipline with four (4) or more years of relevant experience, preferably with auto-immune diseases

Required Experience and Skills:

• Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues

• Experience using Meso Scale Discovery , Luminex and ELISA to measure analytes in serum, plasma, supernatant or cell lysates

• Experience developing ex-vivo models to assess immune responses from human whole blood, PBMCs, and various immune cell subsets

• Experience with cell-based assays including primary cell and reporter cell assays

• Proficiency in data analysis using Excel, GraphPad Prism, Flow Jo

Preferred Experience and Skills:

• Experience with Western Blots for samples generated from cell pellets and tissue

• Experience with protein quantification techniques from tissue samples

• Independent, creative life scientist that can identify key questions from the available data and design experiments to address them

• Versatile, enthusiastic, and detail oriented

• Experience mentoring junior scientists at the bench to learn new techniques

• Excellent problem-solving and organizational skills

• Strong interpersonal and communication skills including presenting data to all levels of the organization

• Ability to work in fast-paced and matrix environment to meet project goals

#EligibleforERP

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)

Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights (https://www.eeoc.gov/sites/default/files/2022-10/22-088_EEOC_KnowYourRights_10_20.pdf)

EEOC GINA Supplement​

Pay Transparency Nondiscrimination (https://www.dol.gov/sites/dolgov/files/OFCCP/pdf/pay-transp_%20English_formattedESQA508c.pdf)

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/)

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

Under New York State, Colorado State, Washington State, and California State law, the Company is required to provide a reasonable estimate of the salary range for this job. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected salary range:

$135,500.00 - $213,400.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here (https://www.benefitsatmerck.com/) .

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic/International

VISA Sponsorship:

Yes

Travel Requirements:

No Travel Required

Flexible Work Arrangements:

Not Applicable

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

YES

Job Posting End Date:

07/5/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date: 07/05/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R300345