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Job Description

We are on a quest for cures and are committed to be the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal to take our Company’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

The Discovery Biologics Department is seeking a Principal Scientist to join a Cell Science team that leverages cell engineering and innovative bioassays to drive design and progression of biotherapeutics. Cell engineering is integral to Discovery Biologics and enables antibody discovery, functional characterization, and development of pipeline molecules. The Principal Scientist, Cell Engineer will lead a comprehensive cell engineering function with subject matter expertise to build next generation reporters, expression cassettes, and knockouts and consolidate efforts across multiple Discovery Biologics sites. The successful candidate will possess a broad and strong technical background in cell and molecular biology as well as in emerging functional genomics technologies and be capable of implementing and adapting these novel approaches to cell line engineering. This role will be based in South San Francisco and will work collaboratively with scientists and teams across our Company research sites.

We recognize that the diversity in our team is our strength and are committed to creating an inclusive environment for all employees. Successful candidates must demonstrate inclusive behaviors in working with a diverse group of scientists to drive our core mission.

Key Responsibilities

• Production level support for mammalian cell line needs for cell binding and functional assays across the span of the Discovery Biologics organization and key partners within our Company's network.

• Centralize vector designs, gene synthesis, lentiviral production, and out-sourced vendors for end-to-end work across the Discovery Biologics organization.

• Innovate on lentiviral, landing-pad, transposon, plasmid methods for mammalian stable cell line development.

• Explore next-generation reporters, proximity assays, and bi-cistronic expression cassettes.

• Deploy CRISPR gene editing for precision cellular models to enable mechanism of action studies and analytical characterization of molecular concepts.

• Contribute to and lead the authoring of patents and external publications.

• Present research findings at group meetings, project meetings, and at external meetings.

• Actively develop talent, strategically maximize diversity to complement and strengthen our team.

• Foster a high-performance culture of collaboration, engagement, self-accountability and inclusion.

Qualifications & Experience

• Ph.D. or equivalent with 8 or more years of professional experience or Master’s degree with 10 or more years of professional experience or Bachelor’s degree with 14 or more years of professional experience.

Required Skills:

• Deep knowledge and experience with mammalian cell engineering and generation of cell lines and clones to enable functional assays and mechanism of action studies.

• Experience working with disease-specific cell models and optimizing nucleic acid delivery via lipofection, nucleofection, and/or viral transduction.

• Expertise with molecular biology and design strategies to enable building of next generation reporters, expression cassettes, and knockouts.

• Cell culture experience with a variety of human cell types including lymphoid & myeloid derived cell lines.

• Experience with FACS-based methods for characterizing cell surface expression.

• Transcript/protein quantification assays including RT-qPCR; d/ddPCR, RNA-seq, ELISA, and/or our Company.

• Detail-oriented, highly organized, and able to multi-task with multiple projects.

• Proven track-record working with multiple vendors and contract research organizations to build on internal capabilities via outsourcing.

• Strong oral and written communication skills.

Preferred Skills

• Experience will laboratory automation such as Tecan, Biomek, Hamilton, or similar.

• Relevant experience with the development of biotherapeutics and general interest in functional characterization of large molecules.

• An innovator who proactively seeks opportunities to share their knowledge and enthusiasm.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)

Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.

We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

EEOC Know Your Rights (https://www.eeoc.gov/sites/default/files/2022-10/22-088_EEOC_KnowYourRights_10_20.pdf)

EEOC GINA Supplement​

Pay Transparency Nondiscrimination (https://www.dol.gov/sites/dolgov/files/OFCCP/pdf/pay-transp_%20English_formattedESQA508c.pdf)

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/)

U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.

Expected US salary range:

$167,700.00 - $263,900.00

Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed here (https://www.benefitsatmerck.com/) .

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

Not Indicated

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

10/1/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date: 10/01/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R309982