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At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Chemical Research

Job Category:

Scientific/Technology

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for an Associate Scientist, Discovery Chemistry.

A pre-identified candidate for consideration has been identified. However, all applications will be considered.

Purpose: We are seeking an experienced, highly skilled, and motivated analytical and separation scientist to join our team in Spring House, PA as an Associate Scientist in Discovery Chemistry. In this laboratory-based position, the successful candidate will provide high throughput purification to support medicinal chemistry efforts, with a particular emphasis on peptide projects. This includes purifying compounds from focused chemical libraries or singleton samples at µg to grams using various techniques, such as mass-directed reversed-phase high performance liquid chromatography (RP-HPLC). The candidate will work closely with scientists from Discovery Chemistry and Discovery Process Research to expedite compound design-synthesis-test iterations. Strong communication skills and the ability to thrive in a team-oriented, results-driven environment are essential. Additionally, the candidate must possess strong interpersonal skills to influence collaboration in a multidisciplinary setting.

You will be responsible for :

• Develop, implement, operate, optimize, and maintain efficient workflows and instrumentations in a highly automated setting for the analysis and purification of compounds from medicinal chemistry projects, particularly in peptide synthesis singletons and libraries utilizing RP-HPLC.

• Conduct high-throughput purification work, including crude sample method screening, purification, quality control, and distribution of purified samples specifically for peptide applications using reversed-phase HPLC.

• Optimize workflows for maximum efficiency and deliver fast-turnaround purification services tailored to peptide needs.

• Develop methods to address various requirements in peptide drug discovery and related modalities.

• Present data and reports at internal and external scientific meetings as appropriate, focusing on advancements in peptide purification strategies.

• Act as the senior member in the laboratory by providing hand-on training of new hires, mentoring junior team members, and leading lab operations efforts.

• Collaborate with the vendors to implement new instrumentation, troubleshoot issues and ensure the smooth operation of instruments.

Qualifications

Education:

• A minimum of a Bachelor’s degree or Master’s degree in Analytical, Synthetic, Organic, Medicinal chemistry or related chemistry field is required.

Experience and Skills:

Required:

• Minimum of 4 years of relevant analytical and purification experience is required. Master’s degree preferred.

• Expert knowledge of modern analytical and purification techniques, such as UPLC and open bed mass-directed preparative RP-HPLC is required.

• Proven experience in lab automation and compound distribution logistics related to peptide projects, along with expertise or strong interest in automation and managing large data sets is required.

• Independent thinking and the ability to effectively collaborate in a highly matrixed environment is required.

• Excellent oral and written communication skills, including the ability to prepare presentations is required.

If you are enthusiastic about advancing medicinal peptide chemistry with innovative purification techniques, we encourage you to apply.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

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