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At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

Scientific/Technology

All Job Posting Locations:

US026 PA Spring House - 1400 McKean Rd

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for Sr. Principal Scientist, Cellular & Mechanistic Pharmacology to be in Spring House, PA.

Purpose: The Discovery Technologies & Molecular Pharmacology (DTMP) team within Therapeutics Discovery contributes to the delivery of high-quality leads across drug modalities including small molecules, large molecule biologics, and cell therapies. We apply innovative, and therapeutically relevant cellular assays from target concept through the lead optimization process. Join our team! We’re looking for a talented scientist with an immunology and/or oncology background, deep expertise in disease biology and cellular pharmacology, and a passion for finding innovative therapeutics to treat diseases with high unmet medical need.

You will be responsible for :

• Support early stage and late-stage immunology and or oncology programs via conception and implementation of cellular assays to address translatability, mechanism of action, and liability assessment.

• Act as a key liaison between DTMP and program teams, driving project strategy and execution, in partnership with cross-functional colleagues.

• Analyze and present data at program team meetings, in-house seminars, leadership meetings and external scientific conferences, and publish research in high-quality journals.

Qualifications / Requirements:

Education:

• Minimum of Ph. D. in Immunology and or Oncology, cell biology or equivalent with post-doctoral experience and a minimum of 10 years of experience developing and applying novel cellular assays in a pharmaceutical industry/biotech setting, is required.

Experience and Skills:

Required:

• Proven track record in managing immunology and or oncology-focused drug discovery programs across diverse modalities, in an industry setting.

• Deep expertise and proven accomplishments in de novo cellular pharmacology assay development, including complex immune or tumor cellular models and high-throughput technology platforms.

• Experience with generating translationally relevant cell models such as primary cells, 3D cultures, whole blood, and/or co-cultures.

• Expertise collecting and analyzing data using high dimensional approaches such as high content imaging, flow cytometry, transcriptional readouts, and or multiplexed secretome analysis.

• Strong experience as a leader, problem solver and team collaborator able to facilitate understanding between biologists, chemists, and data scientists.

• A demonstrated ability to apply novel approaches to address complex biology questions, as evidenced through strong peer-reviewed publications.

• Excellent written communication, verbal communication, and oral presentation skills.

• Demonstrated influence, negotiation, and conflict resolution skills.

Preferred:

• Expertise in assay automation.

• Expertise developing assays in advanced 3D cell models.

• Expertise in immunology and/or oncology therapeutic areas.

• Experience working with and/or guiding external collaborators in industry or academia.

• Experience in protein degradation is a significant plus.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.