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Job Description

Are you passionate about revolutionizing drug delivery and shaping the future of pharmaceutical sciences? Join our dynamic and multidisciplinary research group that is at the forefront of drug discovery and development. Discovery Pharmaceutical Sciences (DPS) is a multidisciplinary research group that enables drug discovery and drug product development through application of pharmaceutical science to drug delivery research from target identification through clinical candidate selection for both small and large molecules as well as vaccines. DPS influences molecular design of these clinical candidates through physicochemical property profiling and application of insights to better understand and resolve drug product developability risks. Our deliverables include identification of oral and parenteral preclinical formulations for pharmacology and toxicology studies across modalities (small molecules, peptides, biologics, and vaccines). We closely collaborate with other key functions required for selection and progression of clinical candidates, including Biology, Medicinal Chemistry, Drug Safety, Process Research, Vaccine Development, Analytical Research, Drug Metabolism and Pharmacokinetics. In aggregate, our team enables the transition of optimized molecules from discovery to clinical formulation development with clinical formulation strategies in place.

Primary Responsibilities

DPS in West Point, PA is seeking an Associate Principal Scientist to join our team. This position requires understanding of formulation development, process development and a track record of successful contributions to drug product development. The candidate should have a creative passion for identifying and applying effective drug delivery technologies and pharmaceutics methods as well as a history of driving results and rapidly progressing ideas from conception to in vitro/in vivo evaluation.

In this role the candidate will:

• Work as part of a team focused on the discovery of novel therapeutics through support of molecular profiling, de-risking strategies, and collaborate effectively within and across functional areas.

• Design and execute physicochemical characterization and formulation development across modalities for preclinical and first-in-human studies.

• Identify and champion impactful pipeline-driven innovations to solve unique Discovery program challenges of delivery of small molecules and vaccines.

• Direct and advocate for innovative drug delivery technologies, deploying them to pipeline assets.

• Perform technical data analysis and drive communications both verbally and through written documents and reports, to the local team, across functions, and external to our Company.

• Actively explore external opportunities (academia and industry) to engage innovative technologies related to drug delivery and pharmaceutics.

• Enhance our external collaboration network (academia and industry) and guiding our scientific presence externally through publication, patents, and conferences.

Education

• Ph.D. with 4 years of experience or B.S. or M.S. with 10 years of relevant industrial experience in Pharmaceutical Sciences, Chemistry, Biochemistry, Chemical Engineering, Biomedical Engineering, Biochemical Engineering or related discipline or relevant industry experience.

Required Experience and Skills

• Experience in leading formulation development, driving innovative research in characterization and product development of small molecules, peptides, proteins, or vaccines.

• Demonstrated experience solving discovery and early development program challenges by leveraging strong scientific fundamentals in related subject areas including organic chemistry, analytical chemistry, physical chemistry, biopharmaceutics, process development, or engineering.

• Strong leadership/inter-personal skills and motivation to work in a team environment with cross-functional interactions.

• Demonstrated ability to independently design, execute and lead complex experiments and data analysis.

• Track record of working effectively with team-members of diverse skill sets and backgrounds.

• Excellent communication skills with ability to present scientific concepts to diverse audiences.

Preferred Experience and Skills

• Strong background in drug discovery and development with expertise in formulation and delivery systems.

• Product development across mixed modalities and routes of administration

• Experience leading development projects at an enterprise level.

• Capable of mentoring individuals in a peer-to-peer fashion and as a technical mentor.

• Advanced computation, data analysis, and visualization skills.

• Strong record of external peer-reviewed publications, patent applications or patents.

#EligibleforERP

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders). Please understand that, as permitted by applicable law, if you have not been vaccinated against COVID-19 and an essential function of your job is to call on external stakeholders who require vaccination to enter their premises or engage in face-to-face meetings, then your employment may pose an undue burden to business operations, in which case you may not be offered employment, or your employment could be terminated. Please also note that, where permitted by applicable law, the Company reserves the right to require COVID-19 vaccinations for positions, such as in Global Employee Health, where the Company determines in its discretion that the nature of the role presents an increased risk of disease transmission.

Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld)

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We are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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U.S. Hybrid Work Model

Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence. This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Regular

Relocation:

Domestic

VISA Sponsorship:

No

Travel Requirements:

10%

Flexible Work Arrangements:

Not Applicable

Shift:

1st - Day

Valid Driving License:

No

Hazardous Material(s):

n/a

Job Posting End Date:

06/1/2024

*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Job Posting End Date: 06/01/2024

A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID: R294702